Tetracycline이 白鼠齒質形成期에 미치는 影響에 關한 實驗的 硏究
THE EFFECT OF TETRACYCLINE ON DENTINOGENESIS OF DEVELOPING ALBINO RATS
박인자,
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박인자 ( ) - 서울대학교 대학원 치의학과 소아치과학
KMID : 0358919760030010012
Abstract
The study is about the effect of tetracycline-HC1 on the amelogenesis and the dentinogenesis of the albino rats by means of histochemistry and fluorescence microscopy.
Females in oestrus were mated overnight and examined the next morning for evidence of copulation. The mothers were intraperitonealy injected with a single dose of tetracycline-HCJ from the eighth to tenth day of gestation.
The heads of new born rats were fixed in Carnoy´s solution and 10% formalin solution.
The staining methods were alizarin red S stain, PAS reaction, colloidal iron reaction, Morin´s stain and hematoxylin-eosin stain,
The results were as follows:
1. By the single injection of tetracycline, the matrix formation of enamel and dentin were disturbed, and the shape and arrangement of ameloblast and odontoblast were distorted.
2. It seemed that, with the higher dose of tetracycline, the positive materials of PAS reaction were increased in the disturbed enamel and dentin matrix, but those of alizarin red S stain and colloidal iron reaction were decreased.
3. The fluorescence intensity in the disturbed enamel and dentin matrix were higher than the other areas and appeared to increase gradually with the higher dose of tetracycline.
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